Advanced methods for visualisation of different cell organs, human cells, tissues and whole-body scans are becoming increasingly important in clinical research. Researchers in the region have excellent possibilities to use a full range of advanced imaging instruments. The Uppsala PET Centre has been world-renowned for its leading PET chemistry. Uppsala has well-integrated clinically oriented PET-MRI and PET-CT cameras. The integration of PET, CT and MRI is possible not only by the advanced equipment itself but also by being physically connected to the PET centre and cyclotron facilities centrally located at the University Hospital.

Due to research breakthroughs, the success of radiotherapy in cancer treatment is increasing while side effects are decreasing. Further improvements in cancer therapy require additional support from radiotherapy research infrastructures, from basic clinical research to full-scale clinical investigations with novel methods.

The Preclinical Treatment Center provides small animal systems similar to those used for treating patients, including high-accuracy image-guided irradiation, CT imaging and standard chemotherapy treatment. The efficacy of the irradiation treatment or, for example, novel targeted therapies can be further evaluated using bioluminescence imaging. Combining radiotherapy with the MRI technique in a single device increases the likelihood of being able to beam cancer with greater precision. That can lead to milder side effects and fewer relapses. The technology allows researchers to study in detail what happens in tumours and healthy tissue day by day during a radiation protocol.

Proton beam therapy is an advanced cancer treatment. A major advantage of proton therapy – compared with other radiation treatments – is the potential for reduced risk of radiation injuries. The Skandion Clinic in Uppsala is currently the only clinic in the Nordic region to offer proton radiation treatments. The cell radiation facility offers the opportunity to expose cells to ionising radiation (X-rays and gamma rays) in basic and applied preclinical research, and the research areas range from radiation biology, tumour therapy, neuro-oncology and cancer pharmacology and computational medicine, radiation toxicology, immunotherapy, immunology to microbiology.

Last modified: 2022-06-27