Uppsala hosts several comprehensive large-scale cohort research infrastructures with biobanks.

The prospective observational studies with the highest scientific value are population-based and large, following participants for many years with repeated measurement. Analyses of such studies should be done with modern epidemiological methodology, including directed acyclic graphs and causal inference statistics.

Recurrent measurements of long-term lifestyle factors reduce information bias and offer unique opportunities to investigate changes over time, detailed dose-response relationships and assessment of critical exposure periods. The prospective cohort study with longitudinal exposure information and biological sample collection is an essentially unrivaled and indispensable design for investigating the causes of diseases.

Last modified: 2022-06-21