Infrastrukturer för kohortforskning
Uppsala-Umeå Comprehensive Cancer Consortium (U-CAN)
A national infrastructure that collects samples and structures data from cancer patients (n=22,000).
Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research (SIMPLER)
A national infrastructure with longitudinal cohorts (n=110,000), omics and biobank.
Epidemiology for Health (EpiHealth)
A national cohort (n=25,000) with omics and biobank infrastructure.
Swedish CArdioPulmonary bioImage Study (SCAPIS)
A national infrastructure, one of six nodes with a cohort (n=30,000 women) and biobank.
Uppsala Longitudinal Study of Adult Men (ULSAM)
A local infrastructure with a longitudinal cohort (2 322 men) and biobank, 50 years follow-up.
Prospective Investigation of Vasculature in Uppsala Seniors (PIVUS)
A local infrastructure with a longitudinal cohort (1016 men and women) and biobank, invited 2001 at age 70.
Register-based resource for prostate cancer research (PCBaSe)
A national infrastructure with a register-based database with 80 000 cases of prostate cancer.
A national collaborative infrastructure with one million participants.
Uppsala Abdominal Aortic Aneurysm (AAA) cohort
A local infrastructure with a collection of biological samples from patients with aorta aneurysm.
Sleep and Health in Women (SHE) & Sleep and Health in Men (SHM)
A local infrastructure with cohorts containing detailed investigations of those with snoring symptoms.
Uppsala hosts several comprehensive large-scale cohort research infrastructures with biobanks.
The prospective observational studies with the highest scientific value are population-based and large, following participants for many years with repeated measurement. Analyses of such studies should be done with modern epidemiological methodology, including directed acyclic graphs and causal inference statistics.
Recurrent measurements of long-term lifestyle factors reduce information bias and offer unique opportunities to investigate changes over time, detailed dose-response relationships and assessment of critical exposure periods. The prospective cohort study with longitudinal exposure information and biological sample collection is an essentially unrivaled and indispensable design for investigating the causes of diseases.