The following research infrastructures have financial support from the Disciplinary Domain of Medicine and Pharmacy during 2017-2019.
Array and analysis facility
The Array and analysis facility provides microarray related services based on the Thermofisher Gene Chip 3000 and Gene Titan systems, which includes analysis of mRNA/ncRNA levels, miRNA levels, DNA copy number measurements and whole genome/custom SNP genotyping etc. In addition we provide bioinformatic support and develop algorithms for problems that many users face.
More information www.medsci.uu.se/array-and-analysis-facility/
BioVis - Platform for Biological Visualisation
The Platform for Biological Visualisation, BioVis, provides a unique combination of technology and know-how for visualization of biological samples at the tissue, cell and subcellular level. We specialise in microscopy, electron microscopy, flow cytometry and image analysis. We can offer state of the art electron-, confocal and light microscopy, as well as analytical and imaging flow cytometry and cell sorting.
The Disciplinary Domain of Medicine and Pharmacy at Uppsala University supports BioVis financially, thus the user fees can be kept low. The platform is available for all universities, governmental agencies and private companies. With proper training, provided by us, you can get almost complete access to the equipment at BioVis.
More information www.biovis.uu.se/
Preclinical Cancer Treatment (PCT) Center
The Preclinical Cancer Treatment (PCT) Center provides preclinical and clinical researchers with the possibility to evaluate novel drugs in combination with standard treatments in vivo and to refine current cancer therapies. The facility uses medical systems similar to those used in the clinical setting for treating patients and is equipped with both an advanced cone-beam-CT guided X-ray irradiator and a bioluminescence imaging system. The efficacy of irradiation treatment or of e.g. novel targeted therapies can be further evaluated using bioluminescent imaging.
The PCT Center offers multi-fractionated image-guided radiotherapy, help with irradiation treatment planning, and additional support (i.e. chemotherapy, data analysis etc.)
More information igp.uu.se/infrastructures/preclinical-cancer-treatment/
Hedenstierna translational laboratory
Hedenstierna translational laboratory is one of Scandinavia's most advanced large animal laboratories and is internationally highly renowned. It can perform all kinds of large animal research; advanced surgical interventions in all parts of the body, transplantations, cardiopulmonary bypass, dialysis, respiratory research, all kinds of imaging (e.g., CT-PET and MR-PET) and large animal models for sepsis/antibiotic research and pharmacodynamic and pharmacokinetic studies.
Moreover, basic physiology/pathophysiology as well as model diseases can be studied from the full body and organ perspectives down to single cell reactions. The laboratory is a core facility and has a substantial national and international collaboration.
The major aims of the IMBIM BSL3-Lab are to provide services for design, performance and analyses on BSL3 organisms for internal and external research groups. Our coworkers have a solid experience of research mainly on zoonotic BSL3 viruses, but the facility will be further expanded for studies also on BSL3 bacteria.
IMBIM BSL3-Lab offer all required experience and equipment for isolation, amplification and characterisation of the microorganisms. Since our BSL3-Lab is the only laboratory that handle human pathogens of BSL3-class, we also serve the hospital with analyses that require BSL3-level.
NMR Uppsala is a cross-faculty platform aiming to:
- Give open access to modern NMR spectroscopy to UU researchers.
- Serve as a centre of competence in NMR at UU and optimize the use of resources locally at UU, and the connection to national platforms.
- Increase the understanding and use of modern NMR.
The platform will provide expertise, services, advice and training to the UU research community that may benefit from NMR spectroscopy. The platform comprise a 600 MHz NMR spectrometer equipped with a cryoprobe, headed by a platform manager with a broad experience in NMR.
The platform is supported by strategic infrastructure grants by the Scientific Domain of Medicine and Pharmacy and Department of Chemistry BMC at the Scientific Domain of Science and Technology. Researchers from these entities have priority access at a reduced fee, based on instrument time. This instrumentation provides an excellent local facility for structural determination of compound ranging from complex natural products isolated in small amounts to polypeptides and small proteins, as well as the dynamics of these compounds. It will also allow a multitude of other investigations to be carried out, e.g. studies of ligand-protein interactions and metabolomics.
The instrument is being installed during December 2017, and the recruitment of a platform manager is under way. The platform will be operational during spring 2018.
Awaiting the opening of the Platform NMR Uppsala website, questions can be directed to steering group members
- Jan Kihlberg, institutionen för kemi
The Uppsala PET centre is well known for its established PET chemistry with a world-wide recognition. A clinical PET/MRI system funded by VR was installed in Uppsala in October 2014. The integration of PET and MRI is becoming a reality, not only with the new PET/MR equipment, but also by the fact that the installation itself physically connects the PET Centre, MRI and cyclotron facilities located centrally within the university hospital.
The aim of the PET/MRI platform is partly to offer access time for research projects, but also to facilitate the build-up of a unique imaging “biobank”, including subjects recruited from the U-CAN and EpiHealth cohorts. This resource is to be made available to researchers within Sweden. Individual researchers can, in parallel, also apply for access to patient and subject data from the U-CAN and EpiHealth records as well as “imaging biobank” information.
Are you interested in using the facility?
Please contact Anders Lundberg for an application form.
Preclinical PET-MRI Platform
The Preclinical PET-MRI Platform is a fully equipped preclinical laboratory with radiochemistry lab, cell lab and in vivo imaging lab. We offer services ranging from radiolabeling of molecules to preclinical molecular imaging and translational studies.
The platform has 4 modern small animal scanners with modalities including positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI) and computed tomography (CT). Typical projects may include tracer development, proof-of-pharmacology, BBB-penetration, dose occupancy, PK/PD studies and dosimetry. The academic prices are substantially subsidized.
More information www.ilk.uu.se/platforms/ppp_en/
Uppsala Biobank is an infrastructure for medical research and a center of competence for biobank related matters. We are a collaboration between Uppsala University and Uppsala University Hospital and represents the only biobank of these two principals. Collections include both research samples and samples intended for medical care and treatment.
Uppsala Biobank offer services for e.g. sample management, -collection, -storage, IT-system for traceability of samples and DNA extraction from whole blood.
Uppsala Clinical Research Center (UCR)
Uppsala University Behavioral Facility
Uppsala University Behavioral Facility (UUBF) main aims are to provide administration- and organisation services of behavioral tests for internal and external research groups. We offer a large array of behavioral tasks for mouse, rat and fish, e.g. tasks for exploration, motor behaviors, sensorimotor processing, learning, memory and behavioral profiling.
UUBF provides equipment together with protocols for behavioral experiments (SOPs), and assists with data analysis, interpretation, and advanced statistical analyses. UUBF offers annual third-cycle courses on animal behavior e.g. “How to study behaviour in vertebrates with focus on fish and rodents”.